By John G. Bartlett
Designed to supply easy accessibility to the criteria with which to struggle infectious illness by means of concentrating on choice, right doses, bills, and unwanted effects of antimicrobial brokers, the 2004 notebook of Infectious sickness treatment attracts greatly from strategies made by means of the facilities for affliction keep watch over, the scientific Letter, the yankee health center Formulary carrier, and the AMA's Drug reviews. Tabular fabric has been up to date to incorporate all newly authorized antibiotics, in addition to new suggestions for administration.
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Extra info for 2004 Pocket Book of Infectious Disease Therapy
Caspofungin: Usual maintenance dose of 50 mg/d is reduced to 35 mg/d with moderate hepatic disease; no data for severe hepatic disease. Cefoperazone: Maximum dose is 4 g/d; if higher, monitor levels; with coexisting renal impairment maximum dose is 1–2 g/d. Ceftriaxone: Maximum daily dose of 2 g with severe hepatic and renal impairment. Chloramphenicol: Use with caution with renal and/or hepatic failure; monitor serum levels to achieve levels of 5–20 :g/mL. Clindamycin: Dose reduction recommended only for severe hepatic failure.
Telithromycin: No dose adjustment. Ticarcillin: For patients with hepatic dysfunction and creatinine clearance <10 mL/min, give 2 g/d IV in one or two doses. 1 g) followed by 2 g once daily. Trovafloxacin: For hepatic failure, adjust by indicated dose—indicated dose 300 mg/d IV, use 200 mg/d; indicated dose 200 mg/d IV or po, use 100 mg/d; indicated dose 100 mg/d, use 100 mg/d. Voriconazole: Mild to moderate hepatic insufficiency—6 mg/kg IV q12h × 2, then 2 mg/kg IV q12h. Editors: Bartlett, John G.
Rifampin: Induces hepatic enzymes responsible for inactivating methadone, cortico steroids, oral anti-diabetic agents, digitalis, quinidine, cyclosporine, oral anticoagulants, estrogens, oral contraceptives, and chloramphenicol. Concurrent use of these drugs with rifampin and use in patients with prior liver disease require careful review. Rimantadine: Severe hepatitis disease use 100 mg/d (half dose). Telithromycin: No dose adjustment. Ticarcillin: For patients with hepatic dysfunction and creatinine clearance <10 mL/min, give 2 g/d IV in one or two doses.
2004 Pocket Book of Infectious Disease Therapy by John G. Bartlett